Kirk Dineley, Ph.D

Departments:
Physician Assistant Studies
Email:

Job Title

Adjunct Associate Professor (Midwestern University Medical School)

Bio

Dr. Kirk Dineley earned his Ph.D in Pharmacology from the University of Pittsburgh and his BS in Biology from Pennsylvania State University with over 15. For the past four years, he has been teaching at Midwestern University teaching pharmacology to students of pharmacy and other health services. Prior to this, he was a faculty member in Roosevelt University's new college of pharmacy, where he served as Director of Assessment. Before Roosevelt, he earned tenure at a small, undergraduate liberal arts biology program. Dr. Dineley has authorship on 20 peer-reviewed publications and dozens of meeting abstracts, many of which include students as co-authors.

Education

Ph.D Molecular Pharmacology, University of Pittsburgh
B.S. Biology (Option in Vertebrate Physiology), Pennsylvania State University

Awards & Grants

  • 2013 - Teacher of the Year, Roosevelt College of Pharmacy, Class of 2015
  • 2012 - Student Award for Creative Teaching, Roosevelt University College of Pharmacy
  • 2010 - Elected President of the Phi Kappa Phi Chapter of Francis Marion University
  • 2009 - Award for excellence in research and scholarship, Francis Marion University
  • 2007 - Commencement Speaker for Fall 2007 Graduation Ceremony, Pennsylvania State University (New Kingston Campus)
  • 2003 - Penn Stater of the Quarter Award (New Kensington Campus)
  • 2002 - Doctoral Dissertation with Honors, University of Pittsburgh Department of Molecular Pharmacology
  • 2002 - Marian Kies Memorial Award for exceptional dissertation work in the neurosciences, American Society of Neurochemistry
  • 1999 - Individual Predoctoral Fellowship, American Heart Association, Pennsylvania-Delaware Affiliate (9910111U)
  • 1994 - Graduate with Distinction, Pennsylvania State University
  • 1993 - Elected to Phi Kappa Phi Honor Society

Publications

* indicates student author

1.      Malaiyandi LM, Dineley KE. A characterization of the live-cell cadmium probe Leadmium Green. (In preparation).

2.      Malaiyandi LM, Potempa LA, *Marschalk N, Jungsuwadee P, Dineley KE. Alkylating agent cytotoxicity associated with O6-methylguanine.  In Mechanisms of Cell Death. (In Review).

3.      Kurup S, Dineley KE, Malaiyandi LM, Adewuya R, Potempa L. Head & Neck Cancer: Current Perspectives, Advances and Challenges. In Drugs to Treat Head and Neck Cancers: Mechanisms of Action. Editor JA Radosevich. Springer, Dordrecht.  2013. DOI 10.1007/978-94-007-5827-8_28

4.      *Devinney MJ, Malaiyandi LM, Vergun O, DeFranco, DB, Hastings, TG, Dineley KE. (2009) A comparison of the effects of Zn2+ and Ca2+ on isolated liver mitochondria reveals no evidence for Zn2+-induced permeability transition.  Cell Calcium. 45:447-455

5.      Zhao J, Bertoglio BA, *Devinney MJ, Dineley KE, Kay AR. (2009) The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green.  Analytical Biochemistry. 384:34-41.

6.      Dineley KE, *Zeak JA, *Devinney MJ, Rintoul GL, Reynolds IJ. (2008) Simultaneous detection of intracellular free zinc and free calcium during glutamate stimulation of cultured forebrain neurons.  Journal of Neurochemistry. 106(5):2184-2193.

7.      Dineley KE. (2007) On the use of fluorescent probes to distinguish Ca2+ from Zn2+ in models of excitotoxicity.  Cell Calcium. 42: 341-342.

8.      Vergun O, Dineley KE, Reynolds IJ (2007) Ion Transport and Energy Metabolism. In: Brain Energetics: Integration of Molecular and Cellular Processes (Gibson GE, Diniel G, eds), pp 430-465. Heidelberg, Germany: Springer-Verlag.

9.      *Devinney M.J. Reynolds IJ, Dineley KE. (2005) Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. Cell Calcium. 37: 225-32.

10.  Dineley KE, Richards LL, Votyakova TV, Reynolds I.J. (2005) Zn2+ causes loss of membrane potential and alters production of reactive oxygen species in isolated brain mitochondria.  Mitochondrion. 5(1):55-65.

11.  Malaiyandi LM, Vergoun O, Dineley KE, Reynolds IJ.  (2005) Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and –independent transport mechanisms. Journal of Neurochemistry.  93(5): 1242-1250.

12.  Malaiyandi LM, Dineley KE, Reynolds IJ. (2004) Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release.  Glia. 45:346-53.

13.  Dineley KE, Votyakova TV, Reynolds IJ. (2003). Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration.  Journal of Neurochemistry. 85(3):563-570.

14.  Dineley KE, Malaiyandi LM, Reynolds IJ. (2002). A re-evaluation of neuronal zinc measurements: artifacts associated with high intracellular dye concentration.  Molecular Pharmacology 62(3):618-627.

15.  Dineley KE, Brocard JB, Reynolds IJ. (2002) Elevated intracellular zinc and altered proton homeostasis in forebrain neurons.  Neuroscience 114(2):439-449.

16.  Kress GJ, Dineley KE, Reynolds IJ. (2002) The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes and oligodendrocytes.  Journal of Neuroscience 22(14):5848-5855.

17.  St. Croix, CM, Wasserloos KJ, Dineley KE, Reynolds IJ, Levitan ES, Pitt BR (2002) Nitric oxide-induced changes in intracellular zinc homeostasis are modulated by metallothionein/thionein. American Journal of Physiology 282: L185-L192.

18.  Birder LA, Kanai AJ, de Groat WC, Kiss S, Nealen ML, Burke NE, Dineley KE, Watkins S, Reynolds IJ, Caterina MJ. (2001) Evidence for functional VR1 receptors in urinary bladder epithelial cells. Proceedings of the National Academy of Science, U.S.A. 98(23): 13396-13401.

19.  Aizenman E, Stout AK, Hartnett KA, Dineley KE, McLaughlin BA, Reynolds IJ. (2000) Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. Journal of Neurochemistry 75(5):1878-1887.

20.  Dineley KE, Scanlon JM, Kress GK, Stout AK, Reynolds IJ. (2000) [Zn2+]i toxicity in primary cultures of neurons and astrocytes. Neurobiology of Disease 7(4):310-320.

21.  An B, Dineley KE, Zhang LL, Termin TA, Dou QP. (1997) Involvement of RB kinases and phosphatases in life and death decisions.  Oncology Reports 4:1129-1134.

Accreditation Statement

The ARC-PA has granted Accreditation-Provisional status to the Dominican University Physician Assistant Program sponsored by Dominican University. Accreditation-Provisional is an accreditation status granted when the plans and resource allocation, if fully implemented as planned, of a proposed program that has not yet enrolled students appear to demonstrate the program’s ability to meet the ARC-PA Standards or when a program holding Accreditation-Provisional status appears to demonstrate continued progress in complying with the Standards as it prepares for the graduation of the first class (cohort) of students. Accreditation-Provisional does not ensure any subsequent accreditation status. It is limited to no more than five years from matriculation of the first class.